Fatostatin A

Name	Fatostatin A
Synonyms	125B11 Fatostatin A 2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole Pyridine, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl- 4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole
CAS	125256-00-0

Molecular Formula	C18H18N2S
Molar Mass	294.41
Density	1.125±0.06 g/cm3(Predicted)
Boling Point	474.3±55.0 °C(Predicted)
Solubility	DMSO: ≥ 27 mg/mL
Appearance	solid
Color	Yellow
pKa	3.46±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Last Update：2024-01-02 23:10:35

biological activity	Fatostatin (125B11) is a derivative of diarylthiazole, Sterol regulatory element binding proteins (SREBPs) specific inhibitors of activation. Fatostatin binds to SCAP (srebbp cleavage-activating protein) and inhibits ER-Golgi translocation of SREBPs. Fatostatin can inhibit the growth of cancer cells and enhance the apoptosis of cancer cells.
Target	Value
Cell Line:	DU-145 cells
Concentration:	0.1, 1 μM
Incubation Time:	3 days
Result:	Impaired the IGF1-induced growth at an IC 50 of 0.1 μM. Blocked increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake.
Animal Model:	Four-to-five-week-old homozygous male obese ( ob/ob ) mice (C57BL/6J)
Dosage:	30 mg/kg; 150 μL
Administration:	i.p. injection; daily for 28 days

Last Update：2024-04-09 21:11:58

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Fatostatin A

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